Chapter 1 Background and HistoryWHAT IS MEDICAL GENETICS?WHY IS A KNOWLEDGE OF MEDICAL GENETICS IMPORTANT FOR TODAY'S HEALTH-CARE PRACTITIONER?A BRIEF HISTORYTYPES OF GENETIC DISEASESTHE CLINICAL IMPACT OF GENETIC DISEASEChapter 2 Basic Cell Biology： Structure and Function of Genes and ChromosomesDNA， RNA， AND PROTEINS： HEREDITY AT THE MOLECULAR LEVELTHE STRUCTURE OF GENES AND THE GENOMETHE CELL CYCLEChapter 3 Genetic Variation： Its Origin and DetectionMUTATION： THE SOURCE OF GENETIC VARIATIONDETECTION AND MEASUREMENT OF GENETIC VARIATIONGENETIC VARIATION IN POPULATIONSChapter 4 Single Gene DisordersBASIC CONCEPTS OF FORMAL GENETICSAUTOSOMAL DOMINANT INHERITANCEAUTOSOMAL RECESSIVE INHERITANCEFACTORS THAT AFFECT EXPRESSION OF DISEASE-CAUSING GENESCONSANGUINITY IN HUMAN POPULATIONSX INACTIVATIONSEXZLINKED INHERITANCESEX-LIMITED AND SEX-INFLUENCED TRAITSMITOCHONDRIAL INHERITANCEGENOMIC IMPRINTINGChapter 5 Multifactorial Inheritance and Common DiseasesPRINCIPLES OF MULTIFACTORIAL INHERITANCENATURE AND NURTURE： DISENTANGLING THE EFFECTS OF GENES AND ENVIRONMENTTHE GENETICS OF COMMON DISEASESSOME GENERAL PRINCIPLES AND CONCLUSIONSChapter 6 Clinical Cytogenetics： The Chromosomal Basis of Human DiseaseCYTOGENETIC TECHNOLOGYABNORMALITIES OF CHROMOSOME NUMBERABNORMALITIES OF CHROMOSOME STRUCTURECHROMOSOME ABNORMALITIES AND PREGNANCY LOSSCHROMOSOME ABNORMALITIES AND CLINICAL PHENOTYPESChapter 7 Biochemical GeneticsVARIANTS OF METABOLISMDEFECTS OF METABOLIC PROCESSESChapter 8 Cancer GeneticsCAUSES OF CANCERCANCER GENESMAJOR CLASSES OF CANCER GENESIDENTIFICATION OF INHERITED CANCER-CAUSING GENESIS GENETIC INHERITANCE IMPORTANT IN COMMON CANCERS?CANCER CYTOGENETICSCHROMOSOME INSTABILITY SYNDROMESChapter 9 ImmunogeneticsTHE IMMUNE RESPONSE： BASIC CONCEPTSIMMUNE RESPONSE PROTEINS： GENETIC BASIS OF STRUCTURE AND DIVERSITYTHE MAJOR HISTOCOMPATIBILITY COMPLEXIMMUNODEFICIENCY DISEASESChapter 10 Genetic Testing and Gene TherapyPOPULATION SCREENING FOR GENETIC DISEASEMOLECULAR TOOLS FOR SCREENING AND DIAGNOSISPRENATAL DIAGNOSIS OF GENETIC DISORDERS AND CONGENITAL DEFECTSFETAL TREATMENTGENE THERAPYChapter 11 Genetics and Personalized MedicineA TECHNOLOGY-DRIVEN TRANSFORMATIONTHE IMPACT OF GENOMICSTHE FUTURE OF PERSONALIZED MEDICINEChapter 12 Clinical Genetics and Genetic CounselingTHE PRINCIPLES AND PRACTICE OF CLINICAL GENETICSDYSMORPHOLOGY AND CLINICAL TERATOLOGYBIOETHICS AND MEDICAL GENETICSINDEX