Chapter 1 Overview of Genetics

  1.1 Role of Genetics in Medicine

  1.2 Brief History

  1.3 Classification of Genetic Disorders

  1.4 Future of Medical Genetics

Chapter 2 Molecular Basis of Heredity

  2.1 DNA Structure and Replication

  2.2 Organization of Human Genome

  2.3 Gene Expression

  2.4 Mutation and Polymorphism

Chapter 3 Chromosomal Basis of Heredity

  3.1 Characteristics of Human Chromatin and Chromosomes

  3.2 Sex Determination

  3.3 Variation in Chromosome Number

  3.4 Variation in Chromosome Structure

  3.5 Disorders of Autosomes and the Sex Chromosome

Chapter 4 Single-gene Disorders

  4.1 Pedigree and Pedigree Analysis

  4.2 Autosomal Dominant Disease

  4.3 Autosomal Recessive Disease

  4.4 X-Iinked Dominant Genetic Disease

  4.5 X-1inked Recessive Genetic Disease

  4.6 Y-Iinked Genetic Disease

  4.7 Influencing Factors in the Analysis of Single-gene Disorders

Chapter 5 Mitochondrial Inherited Disorders

  5.1 Structure, Function and Inheritance of Mitochondria

  5.2 Mitochondrial DNA Mutations and Common Mitochondrial Diseases

Chapter 6 Multifactorial Genetic Disorders

  6.1 Characteristics of Multifactorial Traits

  6.2 Inheritance of Multifactorial （Complex） Disorders

  6.3 Factors Affecting Estimation of Recurrence Risk for Multifactorial Disorders

Chapter 7 Human Biochemical Disorders

  7.1 Hemoglobinopathy

  7.2 Hemophilia

  7.3 Collagen Diseases

  7.4 Receptor Protein Disease

  7.5 Enzyme Protein Disease

Chapter 8 Population Genetics

  8.1 Population Genetic Equilibrium

  8.2 Factors Affecting Population Genetic Equilibrium

  8.3 Genetic Load

Chapter 9 Tumor Genetics

  9.1 Chromosomal Aberration and Tumors

  9.2 Oncogene

  9.3 Tumor Suppressor Gene

  9.4 Genetic Mechanisms of Tumorigenesis

  9.5 Hereditary Malignant Tumors

Chapter 10 Diagnosis of Genetic Disorders

  10.1 Symptomatic Diagnosis

  10.2 Presymptomatic Diagnosis

  10.3 Prenatal Diagnosis

Chapter 11 Therapy of Hereditary Disease

  11.1 General Principles and Concerns

  11.2 Surgical, Pharmacological and Dietary Therapy

  11.3 Gene Therapy

Chapter 12 Prevention of Genetic Disorders

  12.1 Genetic Screening

  12.2 Genetic Counseling

  12.3 Genetic Register