医学免疫学（英文原版改编版）（留学生与双语教学用）Medical Immunology / 普通高等教育十三五规划教材.全国高等医药院校规划教材
￥99.80定价
作者： [印]苏尼尔.库马尔.莫汉蒂
出版时间：2017年3月
出版社：清华大学出版社
- 清华大学出版社
- 9787302463085
- 1-1
- 65651
- 16开
- 2017年3月
- 医学
- 基础医学
- R392
- 医学类
- 本专科
内容简介
医学免疫学是一门独立的学科，是研究免疫系统的组织结构和功能的科学。它从不同的角度和水平来揭示免疫系统识别并消除抗原性异物的应答过程和规律，并应用这些规律来阐明免疫相关疾病发生发展的机制，达到防治相关疾病的目的。医学免疫学进展迅速，知识量大，本教材基于*基本的理论和知识，介绍了抗原、免疫器官和免疫细胞、免疫分子（抗体、补体、细胞因子、黏附分子和 MHC等）、免疫应答、免疫预防、免疫治疗、免疫诊断、免疫耐受、免疫相关疾病以及感染免疫等。 本教材适用于医学专业外国留学生的医学免疫学英文教学和本科双语教学。
目录
Chapter 1
Introduction......................................... 1
A BRIEF OVERVIEW OF
IMMUNOLOGY................. 1
HIST ORY OF
IMMUNOLOGY................................... 10
STUDY QUESTIONS....................................................
13
Suggested readingS
.......................................... 13
Chapter 2
Antigen.................................................... 14
DEFINITION.................................................................
14
Epitopes......................................................................
14
Classification of Antigens BASED ON
IMMUNE
RESPONSE............................................. 15
DETERMINANTS OF IMMUNOGENICITY............
15
ANTIGEN
RECEPTORS.............................................. 16
ANTIGENIC
SPECIFICITY......................................... 17
STUDY QUESTIONS
................................................... 18
Suggested
readingS........................................... 18
Chapter 3 Antigen Recognition Molecules
.......................................................................
19
ANTIBODIES—IMMUNOGLOBULINS...................
20
Major Histocompatibility Complex .........
25
STUDY QUESTIONS....................................................
28
Suggested
ReadingS........................................... 28
Chapter 4 The Complement System............
29
Complement
Activation................................. 29
Regulation of the Complement
System .................................................................
31
Biological Consequences of
Complement
Activation.............................. 32
Defects in the Complement System...........
34
STUDY QUESTIONS
................................................... 34
Suggested
readingS........................................... 35
Chapter 5 Organs and Tissues of the
Immune
System................................. 36
LYMPHOID
ORGANS................................................. 36
Contents
STUDY QUESTIONS....................................................
39
Suggested
ReadingS........................................... 39
Chapter 6 Immune
Cells...................................... 41
Lymphocytes...........................................................
41
Phagocytic
Cells................................................. 47
Dendritic Cells
.................................................... 48
STUDY
QUESTIONS.................................................... 48
Suggested ReadingS...........................................
48
Chapter 7 Immune
Response............................ 49
AN TIGEN PROCESSING AND
PRESENTATION...................................................
49
AC TIVATION OF HELPER T
LYMPHOCYTES.......... 51
HU MORAL IMMUNE RESPONSE
(HUMORAL IMMUNITY)....................................
55
PRIMARY AND SECONDARY RESPONSE ...........
58
FA CTORS INFLUENCING ANTIBODY
PRODUCTION........................................................
59
CE LL-MEDIATED IMMUNE RESPONSE
(CELL-MEDIATED IMMUNITY)..........................
60
CYTOKINES..................................................................
64
THEORIES OF IMMUNE
RESPONSE....................... 71
STUDY
QUESTIONS.................................................... 73
SUGGESTED READINGS...........................................
75
Chapter 8 Immunological
Tolerance........... 76
CE NTRAL T CELL TOLERANCE TO
SELFANTIGENS...............................................................
76
PE RIPHERAL T CELL TOLERANCE TO
SELFANTIGENS...............................................................
77
B C ELL TOLERANCE TO
SELF-ANTIGENS........... 78
AR TIFICIALLY INDUCED TOLERANCE IN
VIVO.........................................................................
79
STUDY QUESTIONS....................................................
80
SUGGESTED
READINGS........................................... 80
Contents
目
录
XIV 医学免疫学Meeddiiccaall
IImmuunnoollooggyy
Chapter 9
Hypersensitivity................................ 81
DEFINITION.................................................................
81
GELL AND COOMBS
CLASSIFICATION................ 81
IMMEDIATE TYPE I
HYPERSENSITIVITY.............. 81
TY PEⅡ HYPERSENSITIVITY
REACTION
(ANTIBODY-DEPENDENT CYTOTOXICITY)........
89
TY PEⅢ HYPERSENSITIVITY REACTION
(IMMUNE
COMPLEX-MEDIATED).................... 93
TY PE Ⅳ CELL-MEDIATED
(DELAYED)
HYPERSENSITIVITY..............................................
96
STUDY
QUESTIONS.................................................. 101
SUGGESTED READINGS.........................................
101
Chapter 10
Autoimmunity................................ 102
PR OBABLE MECHANISMS OF
AUTOIMMUNITY................................................
102
AUTOIMMUNE
DISEASES...................................... 107
STUDY QUESTIONS..................................................
109
Suggested
readings......................................... 110
Chapter 11 Immunodeficiency Disorders......
111
PRIMARY
IMMUNoDeFICIENCIES...................... 111
SE CONDARY (ACQUIRED) IMMUNodEFICIENCIES
..................................................................................
117
STUDY
QUESTIONS.................................................. 125
SUGGESTED
READINGs......................................... 125
Chapter 12 Tumor Immunology.........................
126
CANCER:
ORIGIN..................................................... 126
TUMOR
ANTIGENS.................................................. 129
Cancer
Immunotherapy................................ 134
STUDY QUESTIONS..................................................
136
SUGGESTED
READINGs......................................... 137
Chapter 13 Transplantation Immunology......
138
Graft
Rejection................................................... 138
FACTORS FAVORINGALLOGRAFT SURVIVAL......
140
Mechanism Involved in Graft Rejection
................................................................................
142
Tempo of
Rejection............................................ 145
STUDY
QUESTIONS.................................................. 147
SUGGESTED
READINGS......................................... 147
Chapter 14 Immunological
Techniques.......... 149
ST AGES OF ANTIGEN-ANTIBODY
INTERACTIONS....................................................
149
ME ASUREMENT OF ANTIGEN AND ANTIBODY
................................................................................
149
PrecipitationReactions.................................
149
Agglutination
Reaction............................. 154
MO NOCLONAL ANTIBODIES AND
HYBRIDOMA
TECHNIQUE............................. 167
STUDY
QUESTIONS.................................................. 170
SUGGESTED
READINGs......................................... 171
Chapter 15 Immunoprophylaxis &
Immunotherapy...............................
172
IMMUNOPROPHYLAXIS........................................
172
IMMUNOTHERAPY..................................................
179
STUDY
QUESTIONS.................................................. 183
SUGGESTED
READINGs......................................... 183
Chapter 16 Immunity in Viral, Bacterial,
Fungal, and Parasitic
Infections.............................................
184
IMMU NITY IN
VIRALINFECTIONS...................... 184
IMMU NITY IN BACTERIAL
INFECTIONS........... 188
IMMU NITY IN FUNGAL
INFECTIONS................ 197
IMMU NITY IN PARASITIC
INFECTIONS............ 198
STUDY
QUESTIONS.................................................. 204
SUGGESTED
READINGs......................................... 204
Introduction......................................... 1
A BRIEF OVERVIEW OF
IMMUNOLOGY................. 1
HIST ORY OF
IMMUNOLOGY................................... 10
STUDY QUESTIONS....................................................
13
Suggested readingS
.......................................... 13
Chapter 2
Antigen.................................................... 14
DEFINITION.................................................................
14
Epitopes......................................................................
14
Classification of Antigens BASED ON
IMMUNE
RESPONSE............................................. 15
DETERMINANTS OF IMMUNOGENICITY............
15
ANTIGEN
RECEPTORS.............................................. 16
ANTIGENIC
SPECIFICITY......................................... 17
STUDY QUESTIONS
................................................... 18
Suggested
readingS........................................... 18
Chapter 3 Antigen Recognition Molecules
.......................................................................
19
ANTIBODIES—IMMUNOGLOBULINS...................
20
Major Histocompatibility Complex .........
25
STUDY QUESTIONS....................................................
28
Suggested
ReadingS........................................... 28
Chapter 4 The Complement System............
29
Complement
Activation................................. 29
Regulation of the Complement
System .................................................................
31
Biological Consequences of
Complement
Activation.............................. 32
Defects in the Complement System...........
34
STUDY QUESTIONS
................................................... 34
Suggested
readingS........................................... 35
Chapter 5 Organs and Tissues of the
Immune
System................................. 36
LYMPHOID
ORGANS................................................. 36
Contents
STUDY QUESTIONS....................................................
39
Suggested
ReadingS........................................... 39
Chapter 6 Immune
Cells...................................... 41
Lymphocytes...........................................................
41
Phagocytic
Cells................................................. 47
Dendritic Cells
.................................................... 48
STUDY
QUESTIONS.................................................... 48
Suggested ReadingS...........................................
48
Chapter 7 Immune
Response............................ 49
AN TIGEN PROCESSING AND
PRESENTATION...................................................
49
AC TIVATION OF HELPER T
LYMPHOCYTES.......... 51
HU MORAL IMMUNE RESPONSE
(HUMORAL IMMUNITY)....................................
55
PRIMARY AND SECONDARY RESPONSE ...........
58
FA CTORS INFLUENCING ANTIBODY
PRODUCTION........................................................
59
CE LL-MEDIATED IMMUNE RESPONSE
(CELL-MEDIATED IMMUNITY)..........................
60
CYTOKINES..................................................................
64
THEORIES OF IMMUNE
RESPONSE....................... 71
STUDY
QUESTIONS.................................................... 73
SUGGESTED READINGS...........................................
75
Chapter 8 Immunological
Tolerance........... 76
CE NTRAL T CELL TOLERANCE TO
SELFANTIGENS...............................................................
76
PE RIPHERAL T CELL TOLERANCE TO
SELFANTIGENS...............................................................
77
B C ELL TOLERANCE TO
SELF-ANTIGENS........... 78
AR TIFICIALLY INDUCED TOLERANCE IN
VIVO.........................................................................
79
STUDY QUESTIONS....................................................
80
SUGGESTED
READINGS........................................... 80
Contents
目
录
XIV 医学免疫学Meeddiiccaall
IImmuunnoollooggyy
Chapter 9
Hypersensitivity................................ 81
DEFINITION.................................................................
81
GELL AND COOMBS
CLASSIFICATION................ 81
IMMEDIATE TYPE I
HYPERSENSITIVITY.............. 81
TY PEⅡ HYPERSENSITIVITY
REACTION
(ANTIBODY-DEPENDENT CYTOTOXICITY)........
89
TY PEⅢ HYPERSENSITIVITY REACTION
(IMMUNE
COMPLEX-MEDIATED).................... 93
TY PE Ⅳ CELL-MEDIATED
(DELAYED)
HYPERSENSITIVITY..............................................
96
STUDY
QUESTIONS.................................................. 101
SUGGESTED READINGS.........................................
101
Chapter 10
Autoimmunity................................ 102
PR OBABLE MECHANISMS OF
AUTOIMMUNITY................................................
102
AUTOIMMUNE
DISEASES...................................... 107
STUDY QUESTIONS..................................................
109
Suggested
readings......................................... 110
Chapter 11 Immunodeficiency Disorders......
111
PRIMARY
IMMUNoDeFICIENCIES...................... 111
SE CONDARY (ACQUIRED) IMMUNodEFICIENCIES
..................................................................................
117
STUDY
QUESTIONS.................................................. 125
SUGGESTED
READINGs......................................... 125
Chapter 12 Tumor Immunology.........................
126
CANCER:
ORIGIN..................................................... 126
TUMOR
ANTIGENS.................................................. 129
Cancer
Immunotherapy................................ 134
STUDY QUESTIONS..................................................
136
SUGGESTED
READINGs......................................... 137
Chapter 13 Transplantation Immunology......
138
Graft
Rejection................................................... 138
FACTORS FAVORINGALLOGRAFT SURVIVAL......
140
Mechanism Involved in Graft Rejection
................................................................................
142
Tempo of
Rejection............................................ 145
STUDY
QUESTIONS.................................................. 147
SUGGESTED
READINGS......................................... 147
Chapter 14 Immunological
Techniques.......... 149
ST AGES OF ANTIGEN-ANTIBODY
INTERACTIONS....................................................
149
ME ASUREMENT OF ANTIGEN AND ANTIBODY
................................................................................
149
PrecipitationReactions.................................
149
Agglutination
Reaction............................. 154
MO NOCLONAL ANTIBODIES AND
HYBRIDOMA
TECHNIQUE............................. 167
STUDY
QUESTIONS.................................................. 170
SUGGESTED
READINGs......................................... 171
Chapter 15 Immunoprophylaxis &
Immunotherapy...............................
172
IMMUNOPROPHYLAXIS........................................
172
IMMUNOTHERAPY..................................................
179
STUDY
QUESTIONS.................................................. 183
SUGGESTED
READINGs......................................... 183
Chapter 16 Immunity in Viral, Bacterial,
Fungal, and Parasitic
Infections.............................................
184
IMMU NITY IN
VIRALINFECTIONS...................... 184
IMMU NITY IN BACTERIAL
INFECTIONS........... 188
IMMU NITY IN FUNGAL
INFECTIONS................ 197
IMMU NITY IN PARASITIC
INFECTIONS............ 198
STUDY
QUESTIONS.................................................. 204
SUGGESTED
READINGs......................................... 204
